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A rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis

Wan Sulaiman, Wan Aliaa and Fan , Kee Hoo and Basri, Hamidon and Hasan, Shariful and Mohd Sazlly Lim, Sazlyna and Yoke , Loong Foo and Siew , Mooi Ching and Ramachandran, Vasudevan and Mohamed, Mohd Hazmi and Hashim, Hasnur Zaman (2014) A rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis. British Journal of Medicine & Medical Research, 4 (18). pp. 3555-3560. ISSN 3554 - 3560

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Aims and Background: Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are recognized as osmotic demyelination syndrome (ODS. ODS is pathologically characterized by non-inflammatory demyelination of several brain structures with sparing of axons. This condition is usually associated with overzealous correction of hyponatraemia. Acute psychosis as the sole clinical manifestation is extremely rare. Presentation of Case: Hence, we report an interesting case of a middle-aged man who was diagnosed with EPM, following rapid correction of hyponatraemia and subsequently developed acute psychosis. He made a good recovery with supportive treatment alone. Discussion and Conclusion: The possibility of psychosis as a manifestation of ODS, particularly in patients with recent correction of hyponatraemia. The rate of correction of plasma sodium level is the key point for preventing ODS and its complications.

Item Type: Article (Journal)
Additional Information: 5220/37950
Uncontrolled Keywords: Osmotic demyelination syndrome; extrapontine myelinolysis; hyponatraemia; psychosis.
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Depositing User: Dr Hasnur Zaman Hashim
Date Deposited: 27 Aug 2014 15:09
Last Modified: 27 Nov 2014 16:49
URI: http://irep.iium.edu.my/id/eprint/37950

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