Investigation of the effect of temperature cycling on surface features of sulfathiazole crystals during seeded batch cooling crystallization

Abu Bakar, Mohd Rushdi and Nagy, Zoltan K. and Rielly, Chris D. (2010) Investigation of the effect of temperature cycling on surface features of sulfathiazole crystals during seeded batch cooling crystallization. Crystal Growth & Design, 10 (9). pp. 3892-3900. ISSN 1528-7483

Preview

PDF Download (4MB) | Preview

Abstract

The effect of temperature cycling on the surface features of sulfathiazole crystals was investigated using focused beam reflectance measurement (FBRM) and ex situ optical microscopy, scanning electron microscopy (SEM), and atomic forced microscopy (AFM). Smoothing of the crystal surface was observed during heating, while during cooling the smooth crystals showed features growing on their surfaces. These changes on the crystal surface were detected by the FBRM as an increase in the number of coarse counts during heating phases and a drop during cooling phases. Laser beam spreading caused by the surface changes and signal/chord splitting due to the formation of sharp edges are suggested as explanations for the FBRM results. The study shows the capability of FBRM to provide useful information with regard to the changes on the surface of the crystalline products, which could be linked to possible growth mechanisms. The information can be used to avoid problems in the downstream processing or in the final product property due to variations in flowability and friability, which are related to the crystal surface property.

Item Type:	Article (Journal)
Additional Information:	4033/376
Uncontrolled Keywords:	crystallization, FBRM
Subjects:	Q Science > QD Chemistry T Technology > TP Chemical technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy
Depositing User:	Dr Mohd Rushdi Abu Bakar
Date Deposited:	13 Jun 2011 16:13
Last Modified:	20 Dec 2011 07:58
URI:	http://irep.iium.edu.my/id/eprint/376

Actions (login required)

View Item