GC-MS-Based metabolite profiling of cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity

Javadi, Neda and Abas, Faridah and Abdul Hamid, Azizah and Simoh, Sanimah and Shaari, Khozirah and Ismail, Intan Safinar and Mediani, Ahmed and Khatib, Alfi (2014) GC-MS-Based metabolite profiling of cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity. Journal of Food Science and Technology, 79 (6). C1130-C1136. ISSN 0975-8402 (O), 0022-1155 (P)

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Abstract

Cosmos caudatus, which is known as “Ulam Raja,” is an herbal plant used in Malaysia to enhance vitality. This study focused on the evaluation of the α-glucosidase inhibitory activity of different ethanolic extracts of C. caudatus. Six series of samples extracted with water, 20%, 40%, 60%, 80%, and 100% ethanol (EtOH) were employed. Gas chromatography-mass spectrometry (GC-MS) and orthogonal partial least-squares (OPLS) analysis was used to correlate bioactivity of different extracts to different metabolite profiles of C. caudatus. The obtained OPLS scores indicated a distinct and remarkable separation into 6 clusters, which were indicative of the 6 different ethanol concentrations. GCMS can be integrated with multivariate data analysis to identify compounds that inhibit α-glucosidase activity. In addition,catechin, α-linolenic acid, α-D-glucopyranoside, and vitamin E compounds were identified and indicate the potential α-glucosidase inhibitory activity of this herb.

Item Type:	Article (Journal)
Additional Information:	6915/37134
Uncontrolled Keywords:	Cosmos caudatus, diabetes, α-glucosidase inhibitory activity, GC-MS, metabolomics
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. Alfi Khatib
Date Deposited:	02 Jul 2014 12:39
Last Modified:	12 Jun 2018 15:52
URI:	http://irep.iium.edu.my/id/eprint/37134

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