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Effect of cosmos caudatus kunth leaves on the lipid profile of a hyperlipidemia-induced animal model

Perumal, Vikneswari and A. Hamid, Azizah and Ismail, Amin and Saari, Khozirah and Abas, Faridah and Ismail, Intan S. and Maulidiani, and Lajis, Nordin. H. and Khatib, Alfi (2014) Effect of cosmos caudatus kunth leaves on the lipid profile of a hyperlipidemia-induced animal model. Journal of Food Chemistry and Nutrition, 2 (1). pp. 43-51. ISSN 2307-4124 (O), 2308-7943 (P)

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Hyperlipidemia, a metabolic disorder closely associated with the modern life-style and eating habits, is increasingly prevalent among the world population. This study was conducted on obese rats to evaluate the efficacy of Cosmos caudatus leaves as a treatment of hyperlipidemia. Hyperlipidemic conditions were induced in rats by submitting them to a high-fat diet during 3 months. After this, the rats were administered 200 mg/kg body weight of an ethanolic C. caudatus leaf extract or 35 mg/kg body weight atorvastatin for four weeks. The rats treated with the C. caudatus extract showed a significant (P<0.05) reduction of plasma triglycerides, total cholesterol, low density lipoprotein-cholesterol and glucose, and a significant (P< 0.05) increase in high density lipoprotein-cholesterol and Atherogenic Index values. The study indicated that supplementation with C. caudatus has a potential for the treatment of hyperlipidemia.

Item Type: Article (Journal)
Additional Information: 6915/36603
Uncontrolled Keywords: Hyperlipidemia; High Fat Diet;Cosmos caudatus; Atorvastatin; Rats; Obesity
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr. Alfi Khatib
Date Deposited: 14 May 2014 11:04
Last Modified: 20 Jun 2018 15:00
URI: http://irep.iium.edu.my/id/eprint/36603

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