IIUM Repository

Synthesis and characterization of functionalized Se-MCM-41 a new drug carrier mesopore composite

Rahman, Md. Mokhlesur and Yusof, Alias Mohd and Yusan, Sabrie and Ansary , Rezaul H. (2014) Synthesis and characterization of functionalized Se-MCM-41 a new drug carrier mesopore composite. In: International Conference on Nanotechnology in Medicine (NanoMED), 26-28 Feb. 2014, Faculty of Pharmacy, UCL, London.

[img] PDF - Published Version
Restricted to Repository staff only

Download (663kB) | Request a copy

Abstract

Various nanocomposite materials play a number of important roles in modern science and technology including pharmaceutical science. Among these materials, mesoporous materials cover a large number of applications in drug delivery system. Mesoporous Se-MCM‐41 is one of the mesoporous materials used nowadays as a drug carrier. The quantitative incorporation and high dispersion of selenium nanoparticles into MCM-41 has been made possible by the coordination between Se (IV) ion and APTES-anchored MCM-41. The samples were characterized by X-ray powder diffraction, Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM), nitrogen adsorption–desorption via multi point Brunauer, Emmett and Teller (BET) analysis, Raman spectroscopy and UV-Vis diffusion reflection spectroscopy (UV-vis/DRS). X-ray diffraction patterns indicated the existence of the synthesized Se nanoparticles as a crystalline structure with the functionalized material retaining the standard MCM-41 structure. Results from FTIR and Raman spectroscopy demonstrated that the Se and amino groups are incorporated into the Si–O framework. Nitrogen adsorption was used to determine specific surface area, pore diameter and pore volume in the MCM-41 and Se-MCM-41 mesoporous molecular sieves. The increase in cell parameter and the decrease in surface area observed by N2 adsorption–desorption technique were taken as evidence of selenium introduction inside the MCM-41 framework. The presence of a strong absorption band centered at ca. 210 nm in the diffused reflectance UV–vis spectra could explain the presence of hexagonal selenium in the silica network.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Additional Information: 5269/36595
Uncontrolled Keywords: Se-MCM-41, drug carrier
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr Mohd Mokhlesur Rahman
Date Deposited: 12 May 2014 10:33
Last Modified: 23 May 2018 11:22
URI: http://irep.iium.edu.my/id/eprint/36595

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year