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Chemical characterization and antioxidant activity of three medicinal Apiaceae species

., Maulidiani and Abas, Faridah and Khatib, Alfi and Shaari, Khozirah (2014) Chemical characterization and antioxidant activity of three medicinal Apiaceae species. Industrial Crops and Products, 55. pp. 238-247. ISSN 0926-6690

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tCentella asiatica (‘Pegaga’ = Malaysia) is well known plant that has been used as one of the ingredientsin pharmaceutical and cosmetic industries. Using liquid chromatography with diode array and elec-trospray ionization/mass spectrometry (LC–DAD–ESI/MS) analysis, chemical profiling of three differentPegaga extracts (C. asiatica, H. bonariensis and H. sibthorpioides) revealed variations in their metabo-lite profile. Our findings showed that triterpenes of C. asiatica were characterized by the ursane-typetriterpenes (madecassoside, asiaticoside, madecassic acid, and asiatic acid), while the two Hydrocotylespecies consisted of oleanane-type triterpenes (barrigenol derivatives). Other variations are due tothe difference in phenolic and flavonoid constituents. The three Pegaga extracts were also evalu-ated for their total phenolic content (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals, andxanthine oxidase inhibition (XOI) activities. The results showed that C. asiatica has the most potentantioxidant activity (TPC = 72.09 mg/100 g DW; DPPH = 72.99 mikrog/ml; XOI = 87.68 mikrog/ml) as compared toH. bonariensis (TPC = 28.55 mg/100 g DW; DPPH = 22.43 mikrog/ml; XOI = 32.23 mikrog/ml) and H. sibthorpioides(TPC = 56.23 mg/100 g DW; DPPH = 37.86 mikrog/ml; XOI = 14.73. mikrog/ml).

Item Type: Article (Journal)
Additional Information: 6915/36383
Uncontrolled Keywords: C. asiatica; H. bonariensis; H. sibthorpioides; HPLC–DAD–ESIMS
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr. Alfi Khatib
Date Deposited: 18 Apr 2014 15:13
Last Modified: 19 Sep 2017 16:27
URI: http://irep.iium.edu.my/id/eprint/36383

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