Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix

Senjoti, Faria Gias and Jaffri, Juliana Md. and Mandal, Uttam Kumar (2014) Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix. In: International Conference on Pharmaceutical Sciences and Biomedical and Chemical Engineering, February 19 to 20, 2014, Kuala Lumpur.

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Abstract

Gastro retentive tablets of metformin HCl were prepared based on polymer swelling and gas formation. Combination of HPMC and polyethylene oxide was used as both matrix forming agent and swelling agent, while sodium bicarbonate as gas forming agent. Fabricated tablets were optimized by response surface methodology (RSM) utilizing Box Behnken experimental design. The optimized tablets were further characterized by surface morphology, drug release kinetics, accelerated stability study etc. The optimized tablets enabled to float for more than 24 h and sustained the drug release for 12 h.

Item Type:	Conference or Workshop Item (UNSPECIFIED)
Additional Information:	6688/36315 ISBN NO: 9788192710457
Uncontrolled Keywords:	HPMC, PEO, metformin, gastro retentive tablet, RSM, Box Behnken
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr. Uttam Kumar Mandal
Date Deposited:	10 Apr 2014 11:09
Last Modified:	25 Jun 2018 08:39
URI:	http://irep.iium.edu.my/id/eprint/36315

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