Anti bacterial activity of pyranocoumarins and crude extracts of Calophyllum symingtonianum

Aminudin, Nurul Iman and Ahmad, Farediah and Bakhtiar, M. Taher (2014) Anti bacterial activity of pyranocoumarins and crude extracts of Calophyllum symingtonianum. In: International Conference on Natural Products 2014, 18th-19th March 2014, Palm Garden Hotel, IOI Resorts, Putrajaya, Malaysia.

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Abstract

The genus Calophyllum which belongs to Guttderae family is known as ‘bintangor’ by Malay local folks. Previous phytochemicals studies on several Calophyllum species successfully isolated group of pyranocoumarins. In this study, a phytochemical analysis of C. symingtonianum M. R. Hend & Wyatt-Sm. was conducted involving stem barks, leaves and heartwood. Cold extraction method was employed by using dichloromethane and methanol to give the respective crude extracts. Two pyranocoumarins were successfully isolated from stem bark dichloromethane crude extract identified as inophyllum D and isocordato-oblongic acid. Screening on their antibacterial activities were evaluated against B. subtilis, S. aureus, P. aeruginosa, P. putida and E. coli by using disc diffusion (DD), minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) methods. The MBC values showed only the methanol stem bark crude extract inhibited P. aeruginosa and E. coli growth each at 225 ug/mI. The methanol heartwood crude extract moderately inhibited the growth of S. aureus, P. aeruginosa and P. putida each at 450 ug/mL.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	5209/36159
Uncontrolled Keywords:	Calophyllum symingtonianum
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Muhammad Taher
Date Deposited:	02 Apr 2014 11:53
Last Modified:	20 Jun 2018 14:41
URI:	http://irep.iium.edu.my/id/eprint/36159

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