Evaluation of antimalaria activity and acute toxicity of Xetospongia sp

Abdillah, Syamsudin and Noor, Noriah Mohd and Ahmad, Rahmatul Wahidah and Parama Cita, Yatnita (2013) Evaluation of antimalaria activity and acute toxicity of Xetospongia sp. American Journal of Pharmacology and Toxicology , 8 (2). pp. 83-88. ISSN 1557-4962

PDF - Published Version Restricted to Registered users only Download (121kB) | Request a copy

Abstract

We investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and established infections. Acute toxicity of extracts of Xetospongia sp at the dose 5000 mg kg-1 on mice administeredorally exhibited no toxicity, as evident in that fact that no histopathological changes were observed in some essential organs, such as liver, heart, digestive tract and kidney. The ethanolic extracts (50-400 mg kg day-1) exhibited a significant antimalarial activity both in the 4-day early infection test and in the established infection and they were found to be relatively safe up to a dosage of 5000 mg kg-1, with an LD50 value of >500 mg kg-1.

Item Type:	Article (Journal)
Additional Information:	3960/35947
Uncontrolled Keywords:	Xetospongia sp, Antimalarial Activity, Acute Toxicity
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Depositing User:	Prof Noriah Mohd Noor
Date Deposited:	05 Mar 2014 14:59
Last Modified:	06 May 2014 14:53
URI:	http://irep.iium.edu.my/id/eprint/35947

Actions (login required)

View Item