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Procalcitonin clearance for early prediction of survival in critically ill patients with severe sepsis

Mat Nor, Mohd Basri and Md Ralib, Azrina (2014) Procalcitonin clearance for early prediction of survival in critically ill patients with severe sepsis. Critical Care Research and Practice, 2014 (819034). pp. 1-7. ISSN 2090-1305

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Abstract

Introduction. Serum procalcitonin (PCT) diagnosed sepsis in critically ill patients; however, its prediction for survival is not well established. We evaluated the prognostic value of dynamic changes of PCT in sepsis patients. Methods. A prospective observational study was conducted in adult ICU. Patients with systemic inflammatory response syndrome (SIRS) were recruited. Daily PCT were measured for 3 days. 48-h PCT clearance (PCTc-48) was defined as percentage of baseline PCT minus 48-h PCT over baseline PCT. Results. 95 SIRS patients were enrolled (67 sepsis and 28 non-infectious SIRS). 40% patients in the sepsis group died in hospital. Day 1-PCT was associated with diagnosis of sepsis (AUC 0.65 (95% CI, 0.55 to 0.76)), but was not predictive of mortality. In sepsis patients, PCTc-48 was associated with prediction of survival (AUC 0.69 (95% CI, 0.53 to 0.84)). Patients with PCTc-48 > 30% were independently associated with survival (HR 2.90 (95% CI 1.22 to 6.90)). Conclusions. PCTc-48 is associated with prediction of survival in critically ill patients with sepsis. This could assist clinicians in risk stratification; however, the small sample size, and a single-centre study, may limit the generalisability of the finding. This would benefit from replication in future multi-centre study.

Item Type: Article (Journal)
Additional Information: 5608/35857
Uncontrolled Keywords: Serum procalcitonin (PCT), critically ill patients, severe sepsis
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care
Depositing User: Dr. Mohd Basri Mat Nor
Date Deposited: 26 Feb 2014 12:49
Last Modified: 20 Sep 2017 10:44
URI: http://irep.iium.edu.my/id/eprint/35857

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