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Solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of Organic solvents

Abdul Mudalip, Siti Kholijah and Abu Bakar, Mohd Rushdi and Adam, Fatmawati and Jamal, Parveen (2013) Solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of Organic solvents. Journal of Chemical and Engineering Data, 58. pp. 3447-3452. ISSN 0021-9568

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Abstract

Different classes of solvents provide different polarity values, which influence the solubility of pharmaceutical solids. In this article, the solubility of mefenamic acid in different classes of organic solvents, including polar protic, dipolar aprotic, and apolar aprotics at a range of temperatures from (298 to 323) K are reported. It has been found that mefenamic acid shows high solubility in dipolar aprotic solvents (N,N-dimethylacetamide, N,N-dimethylformamide, ethyl acetate, and propanone), moderate solubility in polar protic solvents (ethanol and propan-2-ol), and poor solubility in apolar aprotic solvents (hexane, heptane, and cyclohexane) and water.

Item Type: Article (Journal)
Additional Information: 4033/35192
Subjects: R Medicine > RS Pharmacy and materia medica
T Technology > TP Chemical technology > TP155 Chemical engineering
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Mohd Rushdi Abu Bakar
Date Deposited: 04 Feb 2014 07:04
Last Modified: 29 Feb 2016 02:53
URI: http://irep.iium.edu.my/id/eprint/35192

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