Synthesis and characterization of various type of Azines as potential bioactive agents

How, Fiona Ni Foong and Abdul Malek, Nurfathiah and Solachuddin Jauhari, Arief Ichwan (2013) Synthesis and characterization of various type of Azines as potential bioactive agents. In: 2013 2nd International Conference on Environment, Chemistry and Biology (IPCBEE), 13th - 14th Dec. 2013, Stockholm, Sweden.

PDF - Published Version Restricted to Repository staff only Download (878kB) | Request a copy

Abstract

Five Azines (HMB, ANGDA, HHS, HBrS and EMB) were successfully synthesized and evaluated for their antimicrobial activities against various strains of microbes and cytotoxic activities against human breast adenocarcinoma (MCF-7) and non-small lung carcinoma (H1299) cell lines. All the compounds were characterized with FTIR spectroscopy and further confirmed with single crystal X-Ray diffraction analyses. Screening of antimicrobial activities showed HMB was selectively against K. pneumonia and C. albicans. Cytotoxic activity was evaluated against breast adenocarcinoma, MCF-7 and non-small lung, H1299 cancer cell lines. All of the compounds were active, particularly ANGDA and HMB were tested to be most potent against both MCF-7 and H1299 cell lines.

Item Type:	Conference or Workshop Item (Full Paper)
Additional Information:	6467/34700 (DOI: 10.7763/IPCBEE.2013.V59.9)
Uncontrolled Keywords:	Azine, antimicrobial activity, cytotoxic activity
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Fiona How
Date Deposited:	24 Feb 2014 14:16
Last Modified:	24 Feb 2014 14:16
URI:	http://irep.iium.edu.my/id/eprint/34700

Actions (login required)

View Item