Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats.

Kasmuri, Abdul Razak and Ahmad, Mariam and Sadikun, Amirin and Asmawi, Mohd Zaini (2010) Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats. International Medical Journal Malaysia, 9 (1). pp. 21-26. ISSN 1823-4631

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Abstract

Introduction: The study was done at the aim to assess the functionality and viability of the β cells of the streptozotocin-induced diabetic rats model following repetitive dosage of administration of ethanolic extracts of Andrographis paniculata. Materials and Methods: The diabetic rats were treated with the extracts for fourteen days and at the dose given was 500 mg/kg twice daily. The assessments were made on fasting blood glucose, insulin, and immunohistochemical aspect of β cells before and after treatment. Results: The results showed that there was a signifi cant reduction on fasting blood glucose levels in metformin, 95% and 50% ethanolic plant extracts-treated groups but on insulin level only 95% and 50% ethanolic extracts-treated groups gave a signifi cant reduction (p<0.05). Immunohistochemical assessments revealed that all extract groups and metformin-treated were signifi cantly increased in the population of β cells (p<0.01). Conclusion: This study revealed that the plant extracts showed an ability to promote the growth or rejuvenate the STZdestructed β cells and in turn lower the blood glucose level.

Item Type:	Article (Journal)
Additional Information:	3658/347
Uncontrolled Keywords:	Andrographis paniculata, diabetes mellitus, streptozotocin-induced rats, β cells, hyperglycaemia
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy
Depositing User:	Dr Abdul Razak Kasmuri
Date Deposited:	01 Jun 2011 15:19
Last Modified:	24 Jan 2019 16:23
URI:	http://irep.iium.edu.my/id/eprint/347

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