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In vitro antifungal activity of Rhazya stricta

Khan, Saifullah (2007) In vitro antifungal activity of Rhazya stricta. Pak J Pharm Sci., 20 (4). pp. 274-279. ISSN 1011-601X

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Rhazya stricta is a small glabrous shrub, widely distributed throughout Western Asia from Yemen to Arabia, to the North West Province of India and abundantly found in various regions of Pakistan. Larvicidal and antifungal studies of polar and non polar aerial parts extracts of Rhazya stricta were performed using brine shrimps larvae for larvicidal study and for antifungal study microorganisms, Trichophyton longifusis, Aspergillus flavus, Candida albicans, Microsporum canis and Fusarium solani were used respectively. The methanol fraction showed significant cytotoxicity with LC50 17.809 microg/ml, having mortality rate 73.33% at highest dose. While pet-ether, chloroform and carbon tetrachloride possessed moderate to low cytotoxicity with their LC50 values 49.077 microg/ml, 95.859 microg/ml and 80.489 microg/ml respectively, ethyl acetate fraction showed no cytotoxicity. Results of antifungal studies showed that fractionated samples of methanol and chloroform possessed significant antifungal activities against, Trichophyton longifusis, Aspergillus flavus, Candida albicans and Fusarium solani respectively. Due to these promising results, further in vivo studies over R. stricta must be conducted.

Item Type: Article (Journal)
Additional Information: 6256/34647
Uncontrolled Keywords: Acute Toxicity Tests; Animals; Antifungal Agents; Apocynaceae; Artemia; Fungi; Lethal Dose 50; Plant Extracts
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Depositing User: Assistant Saifullah khan
Date Deposited: 20 Feb 2014 09:21
Last Modified: 22 May 2014 08:39
URI: http://irep.iium.edu.my/id/eprint/34647

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