Survival of lung cancer patients in a resource-limited country

How, Soon Hin and Ng, Teck Han and Kuan, Yeh Chunn and Ab Rahman, Jamalludin and Fauzi, Abdul Rani (2015) Survival of lung cancer patients in a resource-limited country. Asia-Pacific Journal of Clinical Oncology, 11 (3). pp. 221-227. ISSN 1743-7563

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Abstract

Aim: Data on lung cancer survival are lacking in developing countries. Our objectives were to describe the survival of our lung cancer patients and to determine independent prognostic factors affecting survival. Method: All patients diagnosed with lung cancer from August 2007 to August 2010 were recruited from a single referral hospital of the state of Pahang, Malaysia. Detailed demographic data, ECOG (Eastern Cooperation Oncology Group) performance status, stage of disease and treatment were recorded. The date of histology or cytology confirmation was used as the date of entry. Survival time was calculated from the date of entry to the date of death. Results: One hundred forty-nine patients were included for survival analysis. The median age was 62 years and patients were predominantly males (78%) and smokers (78%). The majority had non-small cell lung cancer (NSCLC) (94%); only six patients (4%) had small cell lung cancer. All patients presented with stage 3 or stage 4 disease. Overall median survival was 18 weeks. “No definitive treatment” and “ECOG 3–4” were the significant independent predictors of death, with the hazard ratios of 2.1 (95% confidence interval [CI] 1.4, 3.0) and 1.6 (95% CI 1.1, 2.3) times, respectively. Among NSCLC patients on treatment, 1- and 2-year survival rates were 27% and 15%, respectively. Conclusion: The majority of lung cancer patients in Pahang presented with advanced disease. No definitive treatment and ECOG 3–4 were independent poor prognostic factors.

Item Type:	Article (Journal)
Additional Information:	2987/34285
Uncontrolled Keywords:	factors, lung cancer, median survival, outcome
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	AP Soon Hin How
Date Deposited:	20 Feb 2014 09:14
Last Modified:	11 Mar 2016 17:09
URI:	http://irep.iium.edu.my/id/eprint/34285

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