Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms

Syed Ibrahim, Nurul Huda and Bakhtiar, M. Taher and Darnis, Deny Susanti and Mohamed Amiroudine, Mohamed Zaffar Ali and Ahmed, Qamar Uddin (2014) Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms. Journal of Coastal Life Medicine, 2 (1). pp. 70-75. ISSN 2309-6152 (O), 2309-5288 (P)

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Abstract

Objective: To test direct and indirect antimicrobial properties of α-mangostin towards a number of bacteria and fungi. Methods: The experiment was carried out using broth microdilution and checkerboards methods. Activity of α-mangostin paired with an antibiotic was studied by calculating its fractional inhibitory concentration (FIC). Results: The activity of all four bacteria towards ampicillin, penicillin G, streptomycin and tetracycline showed no interaction with the combination with α-mangostin where the FIC indexes were between the range of 0.5<FICindex>4. Activity of doxycycline on Pseudomonas aeruginosa fell into other set of range, FICindex≥4 which is an antagonism. Conclusions: The FIC index is far away in the range. The coupled antibiotic and α-mangostin is considered synergy in action if it lies in FICindex≤0.5 and it was found that the isolated compound, α-mangostin revealed very low synergistic antimicrobial effects when coupled with antibiotics.

Item Type:	Article (Journal)
Additional Information:	5209/33985
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Muhammad Taher
Date Deposited:	07 Jan 2014 16:21
Last Modified:	29 Jan 2015 16:23
URI:	http://irep.iium.edu.my/id/eprint/33985

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