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Celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats

Saxena, Anil Kumar and Mohd, Fadly and Talib, Norlelawati A. (2013) Celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats. In: XX World Congress on Parkinson"s Disease and Related Disorders, 8-11 Dec 2013 , Geneva, Switzerland.

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Abstract

Objectives: Reduced cerebral blood flow (CBF)has been associated with neurodegenerative disorders. Since neuroinflammation is thought to play a significant role in chronic degenerative neurological disorders like Alzheimer's disease, the present study was planned to,assess the neuroprotective role of celecoxib in Alzheimer's model of rats(2VO). Methods:Experimentally,a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2VO)in rats. After 1 week of acclimatization,fifteen Sprague Dawley rats weighing 200-250 g were equally divided into three groups. Group A served as - sham control, Group B - 2VO, and Group C - 2VO-C treated daily with celecoxib 50 mg/kg, orally following 2VO. On 8th week, all the rats were euthanized and the hippocampi were isolated. Viable neuronal cells in the hippocampal CA-1 region were counted and hippocampal COX-2 mRNA expression and prostaglandin E2(PGE-2)levels were estimated. Results: There was a significant difference in neuronal cell death, increase in COX-2 mRNA expression and PGE-2 levels in 2VO group as compared to sham control group. In celecoxib-treated 2VO-C rats,the viable neuronal cell count of the hippocampal CA-l region was significantly higher as compared to the untreated 2VO group. The hippocampal COX-2 mRNA expression and hippocampal PGE-2 levels were found to be significantly lower in the celecoxib-treated 2VO rats as compared to untreated 2VO rats. Conclusions: The results indicate that celecoxib could be successfully used in the management of Alzheimer's disease. No conflict of interest.

Item Type: Conference or Workshop Item (Full Paper)
Additional Information: 5517/33808
Uncontrolled Keywords: Celecoxib, neuroprotective agent, chronic cerebral hypoperfusion, 2VO rats
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Dr. Anil Kumar Saxena
Date Deposited: 07 Jan 2014 15:30
Last Modified: 07 Jan 2014 15:30
URI: http://irep.iium.edu.my/id/eprint/33808

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