Study of oxidized low density lipoprotein and augmentation index among population

Nazir, Mohd Hakam and Aung, Nilar and Abdullah, Nor Zamzila and Samsuddin, Niza (2013) Study of oxidized low density lipoprotein and augmentation index among population. In: 27th Scientific Meeting of Malaysian Society of Pharmacology and Physiology (MSPP2013), 6-8 September 2013, MS Garden Kuantan. (Unpublished)

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Abstract

Arterial stiffness is defined as the hardening of the arteries due to loss of their elastic properties. Stiffening of arterial wall can be a good biomarker for increased cardiovascular disease thus measuring arterial stiffness is recommended in the preventive management of cardiovascular disease. Arterial stiffness is also associated with a number of cardiovascular disease risk factors like age, smoking, gender, hypertension, obesity, hypercholesterolemia and diabetes. The aim of this research is to study the ox-LDL and augmentation index (AIx) among apparently healthy subjects in ‘Chengal Lempong’ village together with their associations. The subjects (n=85) of age (>18 years) were randomly selected as participants in the study. A sandwich enzyme-linked immunoadsorbent assay (ELISA) was used to measure ox-LDL. The augmentation index (AIx) which reflects the arterial stiffness was determined by using non-invasive applanation tonometry, Sphygmo Cor. The current study showed that mean of the age was 40±8 years with male and female distribution of 38(45%) and 47(55%) respectively. 35.3% of the subjects were obese and 41.2% were overweight. 23 (28%) of them were smoker. There was a significant positive correlation between age and ox-LDL (r = 0.4, p <0.05). AIx was positively correlated with gender (p< 0.05) and smoking (p< 0.05). There was a positive correlation between ox- LDL and AIx ( r = 0.2 at p= 0.05) . The present study found that a higher ox-LDL was related with increased AIx. This showed that the increased arterial stiffness suggesting that oxidative modification of oxidized LDL may affect in the alteration of arterial wall elastic properties.

Item Type:	Proceeding Paper (Poster)
Additional Information:	6053/33734
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr. Nilar Aung
Date Deposited:	13 Jan 2014 16:32
Last Modified:	13 Jan 2014 16:32
URI:	http://irep.iium.edu.my/id/eprint/33734

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