Prevalence of high aldosterone-renin ratio and plasma aldosterone levels among hypertensive patients at a primary care clinic

Omar , Ahmad Marzuki and Abd Rahim, Firdaus and Sukor, Norlela and Shahar, Mohammad Arif and Kamaruddin, Nor Azmi (2013) Prevalence of high aldosterone-renin ratio and plasma aldosterone levels among hypertensive patients at a primary care clinic. Journal of Endocrinology and Metabolism, 3 (1). pp. 40-47. ISSN 2229-9572

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Abstract

Screening test by using aldosterone-renin ratio (ARR) resulted in a higher prevalence (5-15%) of primary aldosteronism than was previously expected but to date there is no such study performed in Malaysia. Objectives: The aim of the study was to determine the prevalence of high ARR (>20) and high plasma aldosterone concentration (PAC) (>150 pg/mL) in hypertensive subjects attending a primary care clinic. Methods: This was a cross-sectional study involving 220 essential hypertension subjects from a primary care clinic in Kuala Lumpur. Bloods for aldosterone, renin and renal profile were taken as specified in previously published protocols. Results: The prevalence of positive test for PA was 7.3%. When either ARR>20 or PAC >150 pg/mL were used, 15.0% and 17.7% of subjects fulfilled the criteria, respectively. Conclusions: The prevalence of hypertensive subjects with high ARR (>20) and PAC (>150 pg/mL) was 7.3%, justifying the need to investigate this group of subjects for PA.

Item Type:	Article (Journal)
Additional Information:	3773/33553
Uncontrolled Keywords:	Primary Aldosteronism, Aldosterone-Renin Ratio, Plasma Aldosterone Concentration,Plasma Renin Activity
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Dr Mohammad Arif Shahar
Date Deposited:	19 Dec 2013 14:22
Last Modified:	22 Jul 2014 12:23
URI:	http://irep.iium.edu.my/id/eprint/33553

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