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Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study

Al-Qaraghuli , Ahmed S and Abdel Wahab, Emad M N and Al-Ani, Imad Matloub Dally and Faisal, Ghasak Ghazi (2013) Effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in sprague dawley rats: A histological study. International Medical Journal Malaysia, 12 (2). pp. 3-10. ISSN 1823-4631

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Abstract

Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate the potential effects of XSYWW on ethanol-induced gastric ulcer in rats by means of histological Study. On a similar basis of treatment, ranitidine, a conventional medication was used as gold standard. Methods: Fifty five male Sprague-Dawley rats (250-300 gm) were divided into four groups. Group I (ethanol treated group) was the control group and gastric ulcers were induced by administering 100% ethanol (1 ml/200 g). Group II (Pre-treatment group) was divided into two subgroups; they were orally fed with 1.0 gm/kg and 2.0 gm/kg respectively of XSYWW solution. Thirty minutes later they were administered with absolute ethanol as in group I. Group III, was given an oral dose of 2gm/kg of XSYWW solution after one hour of ethanol administration. Group IV was given an oral dose of 200mg/kg ranitidine solution after one hour of ethanol administration. Five rats from groups I, III and IV were sacrificed on day 1, 2 and 3 while the animals of group II were sacrificed one hour after ethanol administration. Results: Histological study of the stomachs from ethanol treated rats showed multiple ulcers of various depths that reached the muscularis and the serosa. Conclusion: Pre or post-treated rats with XSYWW showed that XSYWW has protective effect against ethanol-induced gastric mucosal lesion. However, there was a faster and more complete healing process in the ranitidine treated group when compared to the XSYWW treated subjects.

Item Type: Article (Journal)
Additional Information: 5849/33340 scopus
Uncontrolled Keywords: Ethanol, gastric ulcer, ranitidine, Xiang Sha Yang Wei Wan (XSYWW), traditional medicine
Subjects: Q Science > QM Human anatomy
Q Science > QP Physiology
R Medicine > RB Pathology
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Dentistry
Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Assoc. Prof Dr.. Imad Matloub Dally Al-Ani
Date Deposited: 16 Dec 2013 09:23
Last Modified: 18 Dec 2015 10:36
URI: http://irep.iium.edu.my/id/eprint/33340

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