Evaluation of anti-hyperlipidemia activity of Cosmos caudatus leaves in hyperlipidemic induced rat

Perumal, Vikneswari and Abdul Hamid, Azizah and Abas, Faridah and Ismail, Amin and Safinar, Intan and Shaari, Khozirah and Khatib, Alfi (2013) Evaluation of anti-hyperlipidemia activity of Cosmos caudatus leaves in hyperlipidemic induced rat. In: 2nd Asian Regional Conference on System Biology , 8-9 Oct 2013, Bangi.

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Abstract

Background : Hyperlipidemia is known as metabolic disorder in which the prevalence is increasing rapidly worldwide. The objective of this study was to evaluate the effectiveness of C. caudatus leaves in the treatment of hyperlipidemia in obese rats. The induced hyperlipidemic rats were given 200 mg /kg BW of C. caudatus leaves ethanolic extract and 35 mg/kg BW of atorvastatin for 4 weeks. The blood was subjected for lipid profile analysis. Results : C. caudatus for 4 weeks showed a significant (P<0.05) reduced of plasma triglyceride, total cholesterol, LDL and plasma glucose, and significantly (P<0.05) increased HDL and AI value. Conclusions : This study suggests that C. caudatus is potential for the treatment of hyperlipidemia.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	6915/32293
Uncontrolled Keywords:	anti-hyperlipidemia, Cosmos caudatus leaves, hyperlipidemic induced rat, metabolic disorder, hyperlipidemia
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. Alfi Khatib
Date Deposited:	16 Dec 2013 12:47
Last Modified:	16 Dec 2013 12:47
URI:	http://irep.iium.edu.my/id/eprint/32293

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