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Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand

Md. Azahri, Nor Saadah and Kavurma, Mary M. (2013) Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand. Cellular and Molecular Life Sciences, 70 (19). pp. 3617-3629. ISSN 1420-682X

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Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has dual functions mediating both apoptosis and survival of cells. This review focusses on the current regulatory factors that control TRAIL transcription. Here, we also highlight the role of distinct transcription factors that co-operate and regulate TRAIL in different pathological states. A better understanding of the molecular signalling pathways of TRAIL-induced cell death and survival in disease may lead to more sophisticated technologies for novel therapeutic targets. © 2013 Springer Basel.

Item Type: Article (Journal)
Additional Information: 4270/31734
Uncontrolled Keywords: TRAIL; Transcription factor; Regulation; Gene expression; Apoptosis; Cell survival
Subjects: Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences
Depositing User: Wan Afiqah Wan Kamarul Farid (Part Time)
Date Deposited: 14 Jul 2014 15:40
Last Modified: 14 Jul 2014 15:40
URI: http://irep.iium.edu.my/id/eprint/31734

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