Long-Term intraocular pressure changes in patients with neovascular age-related macular degeneration treated with Ranibizumab

Menke, Marcel N. and Salam, Adzura and Framme, Carsten and Wolf, Sebastian (2013) Long-Term intraocular pressure changes in patients with neovascular age-related macular degeneration treated with Ranibizumab. Ophthalmologica, 229 (3). pp. 168-172. ISSN 0030-3755 E-ISSN 1423-0267

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Abstract

Background/Aims: To investigate the long-term effects of multiple intravitreal injections (IVTs) of ranibizumab (Lucentis) on intraocular pressure (IOP) in patients with neovascular age-related macular degeneration. Methods: In 320 eyes, IOP measurements were performed at baseline prior to injection and compared with IOP measurements of the last visit. Correlations between mean IOP change and total number of IVTs, visual acuity or patient age were tested. Results: The mean IOP increase was 0.8 ± 3.1 mm Hg (p < 0.0001). Seven eyes showed final IOP values between 22 and 25 mm Hg. The mean follow-up was 22.7 ± 14.1 months. No further correlations between IOP change and number of IVTs, visual acuity or patient age have been found. Conclusions: This study demonstrated a statistically significant IOP increase in patients treated with repeated injections of ranibizumab. However, IOP increase required no glaucoma treatment during the study. Therefore, repeated injections with ranibizumab can be considered safe with regard to long-term IOP changes in patients without ocular hypertension or glaucoma. Copyright © 2013 S. Karger AG, Basel.

Item Type:	Article (Journal)
Additional Information:	3639/31705
Uncontrolled Keywords:	Age-related macular degeneration; Anti-vascular endothelial growth factor; Intraocular pressure; Ranibizumab
Subjects:	R Medicine > RE Ophthalmology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Ophthalmology
Depositing User:	Dr Adzura Salam
Date Deposited:	17 Dec 2013 10:35
Last Modified:	10 Jan 2024 11:06
URI:	http://irep.iium.edu.my/id/eprint/31705

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