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Antioxidant and alpha-glucosidase activities of phyllanthus niruri extracted with different solvents

Mediani, Ahmed and Abas, Faridah and Khatib, Alfi and Ismail , Intan Safinar and Shaari, Khozirah and Ismail, Amin and Lajis, Nurdin Hj (2013) Antioxidant and alpha-glucosidase activities of phyllanthus niruri extracted with different solvents. The Open Conference Proceedings Journal. ISSN 2210-2892

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Several studies recommended that plants are potential source of bioactive compounds. Phyllanthus niruri is one of plants, which used as a traditional medicine due its richness of phytomedicine metabolites. Identifying the appropriate solvent of extracting these bioactive components from Phyllanthus niruri is thus a crucial step to increase its significance and competence. The influence of drying on its quality and productivity was also evaluated. Three extracting solvents (ethanol, methanol, water) with different ratio were assessed for their effects on biological activities of P. niruri which are dried with three drying methods (air, oven and freeze). The antioxidant activity was evaluated using free radical scavenging ability (DPPH), FRAP and total phenolic content (TPC) assays and antidiabetic by a-glucosidase assay. The selectivity of solvents was also evaluated in terms of the phytochemical compounds present and their concentrations based on quantifying them by LCMS. As function to solvent and drying methods, freeze dried, P. niruri extracted with 80% methanol and water exhibited valuable and higher antioxidant and antidiabetic activities. Principal component analysis (PCA) revealed the relationship among the potential antioxidant activity, total phenolic, a-glucosidase and metabolites levels of the extracts. The present study proposes that P. niruri can be a prominent and constructive medicinal plant.

Item Type: Article (Journal)
Additional Information: 6915/31373
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr. Alfi Khatib
Date Deposited: 27 Sep 2013 10:41
Last Modified: 27 Sep 2013 10:41
URI: http://irep.iium.edu.my/id/eprint/31373

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