Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells

Ghalib, Gaza Murad and Mehdi, Sayed Hasan and Hashim, Rokiah and Sulaiman, Othman and How, Fiona Ni Foong and Ahamed, B. M. Khadeer and Abdul Majid, Amin Malik Shah and Ahmed, Faiyaz (2013) Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells. Journal of Medicinal Plants Research, 7 (20). pp. 1401-1405. ISSN 1996-0875

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Abstract

3,5,4′-Trihydroxy-6,7-dimethoxy-flavone (Eupalitin) has been isolated from the leaves of Asparagus falcatus (Linn.). Anti-proliferation and apoptosis studies were conducted on eupalitin. Results showed that eupalitin exhibited significant cytotoxicity against human colorectal tumor cells. It is found that eupalitin induces the activation of caspases 3/7, a hallmark of apoptosis. The study suggests that the anti-proliferative property of eupalitin towards the human colorectal tumor cells may be probably due to its capability to induce apoptosis in cells.

Item Type:	Article (Journal)
Additional Information:	6467/31142
Uncontrolled Keywords:	3,5,4′-Trihydroxy-6,7-dimethoxy-flavone, eupalitin, Asparagus falcatus (Linn.), cytotoxicity, colorectal cancer, caspases.
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science
Depositing User:	Dr Fiona How
Date Deposited:	05 Aug 2013 09:58
Last Modified:	05 Aug 2013 09:58
URI:	http://irep.iium.edu.my/id/eprint/31142

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