An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract

Abdul Kalam, Azad and Wan Sulaiman, Wan Mohd. Azizi and Z. M., Babar and Labu, Zubair Khalid and Zabin, S. (2013) An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract. Middle-East Journal of Scientific Research, 14 (5). pp. 650-655. ISSN 1990-9233

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Abstract

Inflammation is the complex biological response of vascular tissue to harmful stimuli such as pathogens, damaged cells, or irritants. In the present investigation an attempt was made to screen the anti-inflammatory activity of Basellaalba leaf. From this study, it can be concluded that, Basellaalba possesses a good anti-inflammatory activity. In the cotton pellet induced inflammation and In the carrageenan induced inflammation the animals treated with the plant extract have been shown a significant activity at 500 mg/kg dose (p<0.001) which was comparable with the standard drug. In view of the percentage inhibition also the plant was studied, in which the plant extract was found effective. The antibacterial activity was carried out using different dilutions of methanolic extract against gram positive strains (Staphylococcus aureus, Micrococcus luteus, Bacillus subtilus) and gram negative ones (Pseudomonas aeruginosa) by the cup-plate assay method and minimum inhibitory concentrations (MICs). The different concentrations of extract showed moderate activity against Pseudomonas aeruginosa, Bacillus subtiliswhile weak response against Staphylococcus aureus, Micrococcus luteus and Escherichiacoli. The minimum inhibitory concentration of methanolic extract was 6.25μg/ml against Staphylococcus aureus, Micrococcus luteus, Pseudomonas aeruginosa and Bacillussubtilus and 12.5 μg/ml against Escherichia coli. The overall result of this study indicates that the methanolic extract of Basellaalba have interesting anti-inflammatory and antibacterial properties.

Item Type:	Article (Journal)
Additional Information:	4219/30539
Uncontrolled Keywords:	Antibacterial Activity Inflammation Basellaalba Cotton Pellet Granuloma Carrageenan Phenyl Butazone
Subjects:	Q Science > QD Chemistry Q Science > QR Microbiology > QR180 Immunology R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Depositing User:	Dr Wan Mohd Azizi Wan Sulaiman
Date Deposited:	01 Jul 2013 09:55
Last Modified:	01 Jul 2013 09:55
URI:	http://irep.iium.edu.my/id/eprint/30539

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