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Isolation, characterization and cytotoxic effect exploration of methanolic extract of local medicinal plant clerodendrumn viscosum vent

Abdul Kalam, Azad and Wan Sulaiman, Wan Mohd. Azizi and Tengku Zakaria, Tengku Muhammad Faris and S., Mahmood and H. A., Almoustafa and Labu, Zubair Khalid (2013) Isolation, characterization and cytotoxic effect exploration of methanolic extract of local medicinal plant clerodendrumn viscosum vent. Australian Journal of Basic and Applied Sciences, 7 (4). pp. 641-647. ISSN 1991-8178

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Abstract

Clerodendrumn viscosum vent. is a majestic and broadly used medicinal plant in Bangladesh and India. This research work was carried out to evaluate the phytochemical and biological activity of Clerodendrum viscosum vent. The powdered barks of the roots were extracted with ethanol by a soxhlet apparatus. Ethanol extract was subjected to TLC (Thin Layer Chromatography) examination. A single spot was observed in n-hexane ethyl acetate (4:1) with Rf values 0.5. Phytochemical screening of the ethanol extract showed the presence of carbohydrates, steroids, tannins, flavonoids, saponines and alkaloids. The crude ethanol extract showed toxic behavior against brine shrimp lethality bioassay. The mortality rate of brine shrimp was found to be increased with the increase in concentration of the sample. From the result on the brine shrimp lethality bioassay it can be well predicted that the crude extracts have considerable cytotoxic potency.

Item Type: Article (Journal)
Additional Information: 4219/30538
Uncontrolled Keywords: Clerodendrum viscosum vent, Brine shrimp, Antimicrobial, Lethality bioassay, Phytochemical, Chromatography.
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Wan Mohd Azizi Wan Sulaiman
Date Deposited: 01 Jul 2013 09:32
Last Modified: 21 Jul 2014 09:07
URI: http://irep.iium.edu.my/id/eprint/30538

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