Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats

Ku Zaifah, Norsidah and Ayob, Azizi and Yusuf, Ahmad Asmadi and Yusuf, Kamisah and Othman, Faizah (2013) Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats. Evidence-Based Complementary and Alternative Medicine, 2013 (976967). ISSN 1741-427X

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Abstract

Palm Tocotrienol-Rich Fraction Improves Vascular Proatherosclerotic Changes in Hyperhomocysteinemic Rats Author(s): Norsidah, KZ (Norsidah, Ku-Zaifah)[ 1 ] ; Asmadi, AY (Asmadi, Ahmad Yusof)[ 2 ] ; Azizi, A (Azizi, Ayob)[ 3 ] ; Faizah, O (Faizah, Othman)[ 4 ] ; Kamisah, Y (Kamisah, Yusof)[ 5 ] Source: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE Article Number: 976967 DOI: 10.1155/2013/976967 Published: 2013 Times Cited: 0 (from Web of Science) Cited References: 58 [ view related records ] Citation Map Abstract: This study investigated the effects of palm tocotrienol-rich fraction (TRF) on aortic proatherosclerotic changes in rats fed with a high methionine diet. Forty-two male Wistar rats were divided into six groups. The first group was the control (fed with a basal diet). Another five groups were fed with 1% methionine diet for 10 weeks. From week 6 onward, folate (8mg/kg diet) or palm TRF (30, 60, and 150mg/kg diets) was added into the diet of the last four rat groups, respectively. The high methionine diet raised the plasma total homocysteine and aortic lipid peroxidation, which were reduced by the palm TRF and folate supplementations. Plasma nitric oxide was reduced in the high methionine group compared to the control (3.72 +/- 0.57 versus 6.65 +/- 0.53 mu mol/L, P < 0.05), which reduction was reversed by the palm TRF (60 and 150mg/kg) and folate supplementations. The increased aortic vascular cell adhesion molecule-1 expression in the methionine group (2.58 +/- 0.29) was significantly reduced by the folate (1.38 +/- 0.18) and palm TRF at 150mg/kg (1.19 +/- 0.23). Palm TRF was comparable to folate in reducing high methionine diet-induced plasma hyperhomocysteinemia, aortic oxidative stress, and inflammatory changes in rats

Item Type:	Article (Journal)
Additional Information:	3616/30482
Uncontrolled Keywords:	alpha tocotrienol; folic acid; homocysteine; methionine; nitric oxide; vascular cell adhesion molecule 1
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM214 Diet therapy. Diet and dietectics in disease
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Norsidah Ku Zaifah
Date Deposited:	27 Jul 2013 09:31
Last Modified:	07 Apr 2015 10:59
URI:	http://irep.iium.edu.my/id/eprint/30482

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