Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate

Ravoof, Thahira Begum and Crouse, Karen Anne and Tahir, Mohamed Ibrahim Mohamed and Rosli, Rozita and Watkin, David J. and How, Fiona Ni Foong (2011) Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate. Journal of Chemical Crystallography, 41 (4). pp. 491-495. ISSN 1074-1542

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Abstract

A new tridentate nitrogen-sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized in a monoclinic system with a space group of P 21/n, with crystal cell parameters a = 10.8128 (2) Å, b = 9.3832 (2) Å, c = 18.0352 (4) Å, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen receptor).

Item Type:	Article (Journal)
Additional Information:	6467/300
Uncontrolled Keywords:	Dithiocarbazate, Di-2-pyridylketone, Schiff base, biological activity
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Biomedical Science
Depositing User:	Dr Fiona How
Date Deposited:	11 Nov 2011 10:22
Last Modified:	29 Feb 2012 14:50
URI:	http://irep.iium.edu.my/id/eprint/300

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