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TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype

Zainuddin, Norafiza and Berglund, Mattias and Wanders, Alkwin and Ren, Zhi-Ping and Amini, Rose-Marie and Lindell, Monica and Kanduri, Meena and Roos, Göran and Rosenquist, Richard and Enblad, Gunilla (2008) TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype. Leukemia Research, 33. pp. 60-66. ISSN 0145-2126

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Abstract

Presence of TP53 mutations has been associated with poor prognosis in diffuse large B-cell lymphoma (DLBCL), although this has remained controversial. The TP53 codon 72 polymorphism has shown negative impact on cancer survival, but this has not been analyzed in DLBCL. Furthermore, the MDM2 SNP309 has been associated with earlier age of onset in DLBCL. Here, we investigated the clinical impact of TP53 mutations,MDM2SNP309 and TP53 codon 72 polymorphisms on survival in DLBCL of germinal center (GC) and non-GC subtypes. Thirteen of the 102 (12.7%) patients displayed TP53 mutations. Overall, TP53 mutations had a significant effect on lymphoma-specific survival (LSS, P = 0.009) and progression-free survival (PFS, P = 0.028). In particular, inferior survival was observed in TP53-mutated DLBCLs of GC subtype (LSS, P = 0.002 and PFS, P = 0.006). Neither MDM2 SNP309 nor the TP53 codon 72 polymorphism had an impact on age of onset or survival. Altogether, our data suggests that TP53 mutations are associated with poor outcome in GC-DLBCL patients.

Item Type: Article (Journal)
Additional Information: 4623/29949
Uncontrolled Keywords: TP53 mutation; MDM2 SNP309; TP53 codon 72 polymorphism; Diffuse large B-cell lymphoma; Germinal center subtype; Survival
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User: Dr. Norafiza Zainuddin
Date Deposited: 18 Jul 2013 12:48
Last Modified: 08 Dec 2016 09:37
URI: http://irep.iium.edu.my/id/eprint/29949

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