Synthesis, characterization and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin

Abdul Manan, Mohd Abdul Fatah and Mohamed Tahir, Mohamed Ibrahim and Crouse, Karen Anne and How, Fiona Ni Foong and Watkins, David J. (2012) Synthesis, characterization and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin. Journal of Chemical Crystallography, 42 (2). pp. 173-179. ISSN 1074-1542

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Abstract

New tridentate nitrogen–oxygen–sulfur Schiff base has been prepared from the condensation reaction of S-methyldithiocarbazate and methylisatin. The compound crystallized in triclinic crystal system with space group P - 1, Z = 2, V = 612.92(3) A ° 3 and unit cell parameters a = 6.8540(2) A ° , b = 8.3022(2) A ° , c = 11.5243(4) A ° , a = 79.8186(13)�, b = 90.5224(14)� and c = 72.1362(13)�. Crystal structure reveals that the compound exists in the thione form with the methylisatin moiety is trans with respect to the C3–N2 and C3–S4 bonds whereas the methyl group of the dithiocarbazate moiety is cis with respect to the C3–N2 and C3–S5 bonds. The Schiff base was found to be selectively active against the selected Gram positive bacterial strains (Bacillus subtilis and Staphylococcus aureus)with the inhibition zones of 16 and 12 mm, respectively.

Item Type:	Article (Journal)
Additional Information:	6467/29405
Uncontrolled Keywords:	S-methyldithiocarbazate � Methylisatin �Antibacterial activity
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science
Depositing User:	Dr Fiona How
Date Deposited:	11 Mar 2013 12:23
Last Modified:	11 Mar 2013 12:23
URI:	http://irep.iium.edu.my/id/eprint/29405

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