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Localization of nucleocapsid (NP) antigenic sites by using a panel of monoclonal antibodies against the recombinant NP of Newcastle disease virus

Ahmad Raus, Raha and Ali, Abdul Manaf and Tan, Wen Siang and Mohd. Salleh, Hamzah and Eshagi, Majid and Yusoff, Khatijah (2007) Localization of nucleocapsid (NP) antigenic sites by using a panel of monoclonal antibodies against the recombinant NP of Newcastle disease virus. In: International Conference on Biotechnology Engineering 2007, 8 - 10 May 2007, Kuala Lumpur.

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Abstract

Three different NP antigenic sites were identified using deleted truncated NP mutants purified from Escherichia coli. One of the antigenic sites was located within amino acids 441 to 489 of C-terminal. Two other antigenic sites located within the Nterminal of NP protein from amino acids 26 to 121 and 122 to 375 residues. Identification of NP antigenic sites not only elucidates the NP sequences that are responsible in eliciting immune response, indirectly it also revealed which sequences are exposed on the NP herringbone-like structure.

Item Type: Conference or Workshop Item (Full Paper)
Additional Information: 3911/29279
Uncontrolled Keywords: Monoclonal antibody; nucleocapsid; antigenic sites; Newcastle disease virus
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology > QR355 Virology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User: Dr Raha Ahmad Raus
Date Deposited: 25 Apr 2013 09:31
Last Modified: 25 Apr 2013 09:31
URI: http://irep.iium.edu.my/id/eprint/29279

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