Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma

Yi, Wang and Jun-Ichiro, Ikeda and ., Nur Rahadiani and Mamat, Suhana and Ueda, Yutaka and Tian, Tian and Enomoto, Takayuki and Kimura, Tadashi and Aozasa, Katsuyuki and Morii, Eiichi (2012) Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma. Oncology Letters, 3 (1). pp. 25-29. ISSN 1792-1082 (O), 1792-1074 (P)

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Abstract

Elongator protein 3 (ELP3), the catalytic subunit of the elongator complex of RNA polymerase II, is involved in various functions, including transcriptional elongation, chromatin modification and cytoskeletal regulation. In this study, ELP3 expression was immunohistochemically examined in normal uterus tissue and uterine endometrioid adenocarcinoma tissue. ELP3 was abundantly expressed in both the proliferative and secretory phases of the endometrial cycle. However, ELP3 expression levels varied among cases of endometrioid adenocarcinoma. In patients with endometrioid adenocarcinoma, a low ELP3 expression was correlated to a high T-factor (p=0.036), tumor stage (p=0.001), lymph node metastasis (p<0.001), resistance to chemotherapy (p=0.045), recurrence (p=0.004) and poor prognosis (p=0.003). Univariate and multivariate analyses revealed that a low ELP3 expression was an independent factor for poor prognosis. In conclusion, this is the first study to examine the clinical implications of ELP3 expression in cancer.

Item Type:	Article (Journal)
Additional Information:	4912/29238
Uncontrolled Keywords:	elp; elongator; endometrioid; endometrioid adenocarcinoma; adenocarcinoma; expression; prognostic significance; prognostic; protein expression; protein; endometrial; secretory phase; normal uteru; transcriptional elongation; adenocarcinoma tissue
Subjects:	Q Science > QM Human anatomy
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences
Depositing User:	Nur' Aini Abu Bakar
Date Deposited:	14 Mar 2013 09:37
Last Modified:	14 Mar 2013 09:37
URI:	http://irep.iium.edu.my/id/eprint/29238

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