Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines

Al-Douh, Mohammed Hadi and Sahib, Hayder and Osman, Hasnah and Abd Hamid, Shafida and Salhimi, Salizawati M (2012) Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines. Asian Pacific Journal of Cancer Prevention, 13 (2012). pp. 4075-4079. ISSN 1513-7368

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Abstract

Benzimidazoles 1-4 were obtained using modified synthesis methods and studied for their ability to inhibit cell proliferation of colon cancer cell HCT-116 and breast cancer cell MCF-7 using MTT assays. In the HCT-116 cell line, benzimidazole 2 was found to have an IC50 value of 16.2±3.85 μg/mL and benzimidazole 1 a value of 28.5±2.91 μg/mL, while that for benzimidazole 4 was 24.08±0.31 μg/mL. In the MCF-7 cell line, benzimidazole 4 had an IC50 value of 8.86±1.10 μg/mL, benzimidazole 2 a value of 30.29±6.39 μg/mL, and benzimidazole 1 a value of 31.2±4.49 μg/mL. Benzimidazole 3 exerted no cytotoxity in either of the cell lines, with IC50 values >50 μg/mL. The results suggest that benzimidazoles derivatives may have chemotherapeutic potential for treatment of both colon and breast cancers.

Item Type:	Article (Journal)
Additional Information:	5980/28843
Uncontrolled Keywords:	Benzimidazole - hydroxyl group - benzyloxy group - anti-proliferation - HCT-116 - MCF-7 - MTT assay
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science
Depositing User:	Dr Shafida Abd Hamid
Date Deposited:	05 Feb 2013 16:14
Last Modified:	13 Feb 2013 11:06
URI:	http://irep.iium.edu.my/id/eprint/28843

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