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Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases

Muhamad Bunnori, Noraslinda and Mohamed, Rahmah (2012) Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases. Procedia Computer Science, 11. pp. 36-42. ISSN 1877-0509

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products, including proteases. The role of these proteases in the melioidosis, however, remains obscure. Previous findings have hinted at the inherent pathogenicity of the protease during B. pseudomallei K96243 infection. We chose to study the two major families peptidases, i.e. serine peptidases and metallopeptidases present in B. pseudomallei K96243. The data mining revealed eighty ORFs (open reading frame) that potentially code for these peptidases and have prominent homology with B. pseudomallei K96243 based on prediction of function by bioinformatics approach. The annotations and classification lead forty eight and thirty two putative peptidases belong to serine peptidase and metallopeptidase,respectively. The distribution of 98% from the identified putative peptidase belongs to endopeptidases (EC 3.4.21. and EC 3.4.24.) and exopeptidases (EC 3.4.11., EC 3.4.13., EC 3.4.14., EC 3.4.16. and EC 3.4.17) and another 2% belong to EC 3.5.

Item Type: Article (Journal)
Additional Information: 6604/28704
Uncontrolled Keywords: Burkholderia pseudomallei, Serine, metallopeptidases
Subjects: Q Science > Q Science (General) > Q300 Cybernetics > Q350 Information theory
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Science > Department of Biotechnology
Depositing User: Dr. Noraslinda Muhamad Bunnori
Date Deposited: 23 Jan 2013 11:17
Last Modified: 13 Feb 2013 16:33
URI: http://irep.iium.edu.my/id/eprint/28704

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