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The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients

Radzuan, Hazulin and Myint, Yi Yi and Tun, Ye and Zulkifly, Ahmad Hafiz (2012) The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients. In: 21st Scientific Conference Of The Microscopy Society Malaysia, 22-24 Nov 2012, Kota Bharu, Kelantan.

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Abstract

The reduction of capillary luminal area within dermal microcirculation in diabetic foot patients contributes towards the development of foot ulceration and subsequent failure to heal existing ulcers. We studied 42 subjects, involving 10 controls, 16 patients with neuropathic ulcer and 16 patients with neuroischaemic ulcer. The specimens were taken by using skin punch biopsy and were routinely processed for light microscopy. The mean capillary luminal area (LA) and outer area (OA) were performed by calculating and measuring 3 selected capillaries in each slide of every patient and their percentages of ratio were recorded. We noted that there was significant decrement in percentages of LA:OA among the diseased group as compared to the controls, F(2, 39)=17.54, p<0.05. The Tukey post-hoc comparisons showed that the percentages of LA:OA of neuroischemic group (M=31.89, 95% CI [24.79, 39.00]) was significantly reduced as compared to neuropathic group (M=41.76, 95% CI [37.69, 45.82]) since p<0.05. In conclusion, the reduction of dermal capillary luminal area among diabetic foot patients could be due to the alteration in the microvascular hemeorheology, causing basement membrane thickening as the results of the metabolic disease.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 3635/27249
Uncontrolled Keywords: diabetic foot, dermal microvascular, luminal area, basement membrane
Subjects: Q Science > QM Human anatomy
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Dr Yi Yi Myint
Date Deposited: 14 Jan 2013 10:12
Last Modified: 22 Jun 2017 10:07
URI: http://irep.iium.edu.my/id/eprint/27249

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