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Mixed-genotypes infections with hepatitis C virus in hemodialysis subjects.

Hamzah, Hairul Aini and Mustafa Mahmoud, Mohammed Imad Al-Deen and MR, Seman and BA, Nasuruddin (2012) Mixed-genotypes infections with hepatitis C virus in hemodialysis subjects. The Medical Journal of Malaysia, 67 (2). pp. 199-203. ISSN 0300-5283

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Mixed-genotypes hepatitis C virus (HCV) infections are normally ignored in chronic hemodialysis patients. The aim of this study is to investigate the prevalence of mixed-genotypes infections among hemodialysis patients in Pahang province, Malaysia. Reverse-transcription and polymerase chain reaction methods were performed using two different sets of primers, targeting the 5' untranslated region and nonstructural 5B region. Target region base sequences were obtained by direct sequencing. Discrepancy in outcomes from phylogenetic analysis of both regions suggests double infections. Of 40 subjects in eight hemodialysis centres, evidence of mixed-genotypes infections was found in 5 subjects (12.5%) from three different centres. Four patients were infected with mixed genotypes 3 and 1 and one with genotypes 3 and 4. Cases of mixed HCV genotypes infection were considered high among hemodialysis patients in Pahang. However, further investigation is needed to confirm whether they are true mixed infections or perhaps infection with recombinant virus and also to assess the clinicopathologic characteristics of the infection.

Item Type: Article (Journal)
Additional Information: 5342/27167
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Dr Hairul Aini Hamzah
Date Deposited: 29 Nov 2012 14:54
Last Modified: 29 Nov 2012 14:54
URI: http://irep.iium.edu.my/id/eprint/27167

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