Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia

Caillaud, A and de la Iglesia, P and Campa` s, M and Elandaloussi, L and Ferna´ndez, M and Mohammad Noor, Normawaty and Andree, K and Dioge`ne, J (2010) Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia. Toxicon, 55. pp. 633-637. ISSN 0041-0101

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Abstract

Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA)and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis.Inhibition of PP2A activity and a weak toxicity to the Neuro-2a CBA were also observed.

Item Type:	Article (Journal)
Additional Information:	/2638
Uncontrolled Keywords:	Prorocentrum rhathymum, Protein phosphatase inhibition assay, Neuroblastoma cell-based assay, LC-MS/MS, Okadaic acid
Subjects:	Q Science > QD Chemistry S Agriculture > SH Aquaculture. Fisheries. Angling
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science
Depositing User:	Dr Normawaty Mohammad Noor
Date Deposited:	20 Sep 2011 14:24
Last Modified:	20 Dec 2011 16:44
URI:	http://irep.iium.edu.my/id/eprint/2638

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