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Toxic effects of Sapium baccatum (Ludai) extract in rats (Kesan toksik ekstrak Sapium baccatum (Ludai) ke atas tikus)

Bakhtiar, M. Taher and Mat Alewi, Nur Aizura and Darnis, Deny Susanti and Zamli, Zaitunnatakhin and Ramli, Norazsida and Saad, Nurulwahida (2012) Toxic effects of Sapium baccatum (Ludai) extract in rats (Kesan toksik ekstrak Sapium baccatum (Ludai) ke atas tikus). Sains Malaysiana, 41 (11). pp. 1423-1429. ISSN 0126-6039

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Abstract

Sapium baccatum is usually used as a timber. Its medicinal values are not well known and very little research has been conducted concerning the plant. Consequently, this study was conducted to observe toxicity effects of hexane extract of stem bark of S. baccatum. The toxicity effects were assessed through observation of physiological changes of the rats as well as through gross and histological examinations of its livers. The doses for the treated groups were given intraperitoneally for T2, T3 and T4 group which were given 100, 250 and 500 mg/kg, respectively. Meanwhile, control group (T1) was administered with 80 % PEG 200 only. The observation period was 14 days. If the rat died, it was dissected and the liver was removed and examined. Some physiological effects observed include ataxia and hind-legs paralysis. The gross observations of the livers, growth of abnormal spots and connective tissues attachment to lobes of the livers were observed. The experiment was followed by histopathological observation, which indicated the presence of abnormal hepatocytes with a distorted shape and undefined cell linings for T2 group. Results also indicated an increase in the distortion of hepatocytes, presence of massive cytoplasm and necrosis of hepatocytes for T3 and T4 groups. Therefore, results suggest that non polar extract of the stem bark of S. baccatum may promote toxic effects to the animals.

Item Type: Article (Journal)
Additional Information: 5209/26052
Uncontrolled Keywords: Euphorbiaceae; hexane extract; rats; Sapium baccatum; toxic effects
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Kulliyyah of Science > Department of Biotechnology
Depositing User: Dr Muhammad Taher
Date Deposited: 30 Oct 2012 09:36
Last Modified: 08 Dec 2014 18:09
URI: http://irep.iium.edu.my/id/eprint/26052

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