Batch process modelling and economic evaluation of glucuronidase enzyme production

Kamuri, M Firdaus and Foo, Dominic Chwan Yee and Mel, Maizirwan (2012) Batch process modelling and economic evaluation of glucuronidase enzyme production. Bioprocessing and Biotechniques (S4). pp. 1-7. ISSN 2155-9821

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Abstract

β-glucuronidases enzyme is a valued product in the pharmaceutical industry. This work features the modeling and optimization of β-glucuronidases enzyme production from recombinant E. coli using SuperPro Designer v5, a commercial batch process simulator. The study focuses on designing an economically viable β- glucuronidases enzyme production process. In the base case process, an annual production of 956 batches (corresponding to 8,523 kg) of β- glucuronidases enzyme was made. Seven alternatives production schemes were further developed for increased production using batch debottlenecking strategy. The best alternative scheme was reported to achieve a product yield of 100% increment, with an annual production of 1912 batches of β- glucuronidases enzyme. Economic analysis determined that the proposed alternative scheme has an annual revenue of USD 44M, with a 15.24% gross margin and a 29.44% of return on investment. The payback period of this scheme was estimated to be less than four years.

Item Type:	Article (Journal)
Additional Information:	4085/25805
Uncontrolled Keywords:	β-glucuronidases enzymes, recombinant E. coli, process simulation and optimization, batch processes, debottlenecking, economic analysis
Subjects:	T Technology > TP Chemical technology > TP155 Chemical engineering T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Dr Maizirwan Mel
Date Deposited:	06 Nov 2012 10:21
Last Modified:	06 Nov 2012 10:21
URI:	http://irep.iium.edu.my/id/eprint/25805

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