IIUM Repository

Pharmaceutical application of solid dispersion technology in improving solubility of poorly soluble drugd : a review

Mandal, Uttam Kumar (2011) Pharmaceutical application of solid dispersion technology in improving solubility of poorly soluble drugd : a review. In: Current Issues in Pharmacy. IIUM Press, Kuala Lumpur , pp. 156-177. ISBN 9789674180195

[img]
Preview
PDF (Pharmaceutical application ) - Published Version
Download (272kB) | Preview

Abstract

Together with the permeability, the solubility of a drug plays an important role in determining its oral bioavailability. Nowadays, a majority of the new chemical entities are poorly water soluble candidates. For formulation scientists, it is a big deal to handle those drug candidates in order to formulate a stable pharmaceutical dosage form with appropriate bioavailability. To increase the oral bioavailability of poorly soluble drugs, so far formulation scientists have adopted many chemical and formulation approaches. Out of those approaches, solid dispersion has played an important role for the past few decades. There are many formulation strategies employed to prepare solid dispersions. Solid dispersion mainly increases solubility and dissolution characteristics and thereby also oral bioavailability of poorly soluble drugs. The present review article deals with different strategies of solid dispersion preparation techniques, problems associated with those techniques and how to overcome them in order to improve the solubility as well as bioavailability ofpoorly water soluble drugs.

Item Type: Book Chapter
Additional Information: 4033/18493
Uncontrolled Keywords: Pharmaceutical application, solid dispersion technology, poorly soluble drugs
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr. Uttam Kumar Mandal
Date Deposited: 27 Aug 2012 15:42
Last Modified: 27 Aug 2012 15:42
URI: http://irep.iium.edu.my/id/eprint/25605

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year