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Novel formulation of ‘painkiller’ using vegetarian capsule

Mohamed, Farahidah and Awang, Mohamed and Helaluddin , Abul Bashar Mohammed and Hazim, Anas Abdillah (2012) Novel formulation of ‘painkiller’ using vegetarian capsule. In: IIUM’s 1st International Postgraduate Research Conference, IIPRC 2012, 20-22 Feb 2012, CAC, IIUM Gombak.

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Abstract

Solid dosage forms can be generally divided into two broad classes, i.e. tablet and capsule. Although the use of tablet is more complicated in terms of formulation, the simpler capsule has inherent problem of having the origin of animal for its gelatin, major constituent of hard gelatin capsule shell. There are a few notorious shortcomings associated with the employment of bovine hard gelatin capsule. Although the source of bovine can be certified halal, but the way the slaughtering is conducted could be an issue. Moreover, the risk of contracting a group of fatal neurodegenerative diseases known as Transmissible Spongiform Encephalopathies (TSEs), especially bovine spongiform encephalopathy (BSE) is highly exposed to the consumers of this bovine-derived gelatin. Therefore, objective of this study is to formulate a painkiller with suitable excipients and encapsulate the powder mix into hard vegetarian capsule. The painkiller of choice is a Non-steroidal Anti-Inflammatory Drug (NSAID) namely Mefenamic Acid, of which the proprietary name is Ponstan®. Several formulation variables were investigated including powder flow properties for each of the ingredients and the powder mix. The effect of the powder mix towards disintegration time of the capsule was evaluated. The disintegration time were compared to that reference drug, Ponstan® capsule. It was found that, each of the ingredients represent different flow properties that contributed to formulation challenge. However, regardless of different ratios of excipients, the disintegration times of the Mefenamic acid vegetarian capsules (MAvege) were within regulatory requirement. In addition, since all excipients employed were of plant origin, the results suggest that this novel formulation of painkiller could be the first promising alternative painkiller suitable for vegetarian.

Item Type: Conference or Workshop Item (Lecture)
Additional Information: 4341/25023
Uncontrolled Keywords: vegetarian capsule; Ponstan® capsule; disintegration test; gelatin
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Assoc Prof Farahidah Mohamed
Date Deposited: 14 Jan 2013 13:13
Last Modified: 13 Feb 2013 20:33
URI: http://irep.iium.edu.my/id/eprint/25023

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