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Histopathological evaluation of skin wound healing in rabbits treated by systemic dexamethasone

Kashmola, Muhanad Ali Hamdon and Al-Ani, Imad Matloub Dally and Mustafa, Nazih Shaban and Mustafa Al-Ahmad, Basma Ezzat (2012) Histopathological evaluation of skin wound healing in rabbits treated by systemic dexamethasone. Annals of Microscopy, 12. pp. 27-33. ISSN 0219-2209

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Abstract

The present study was designed to evalurate the effect of dexamethasone on skin wound healing. Fifteen albino rabbits of 6.5 months age were used; an incision and suture was performed on the back skin of ten experimental rabbits previously treated with daily intramuscular injection of 2ml ampoule containing 4 mg dexamethasone for one month and on fi ve control rabbits received 2ml normal saline for the same period. Biopsies of operated skin after 10 days of incision were processed for histopathological evaluation. Histological examination showed delay healing in experimental group in comparison to control group. It is concluded that prolonged use of dexamethasone or misuse of this drug suppress wound healing.

Item Type: Article (Journal)
Additional Information: 5849/24867
Uncontrolled Keywords: skin, dexamethasone, rats, wound healing
Subjects: Q Science > QM Human anatomy
Q Science > QP Physiology
R Medicine > RL Dermatology
R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Dentistry
Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Assoc. Prof Dr.. Imad Matloub Dally Al-Ani
Date Deposited: 13 Aug 2012 08:21
Last Modified: 18 Dec 2015 10:43
URI: http://irep.iium.edu.my/id/eprint/24867

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