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Predictors of in-hospital mortality in primary intracerebral haemorrhage in East coast of Peninsular Malaysia

Rathor, Mohammad Yousuf and Abdul Rani, Mohammed Fauzi and Ab Rahman, Jamalludin and How, Soon Hin and Abdul Rashid, Mohd Amran and Che Abdullah, Shahrin Tarmizi and Omar, Ahmad Marzuki and Shah, Anis (2012) Predictors of in-hospital mortality in primary intracerebral haemorrhage in East coast of Peninsular Malaysia. Neurology Asia, 17 (2). pp. 93-99. ISSN 1823-6138

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Abstract

Background and Objectives: Despite much medical progress, stroke remains a leading cause of death and disability. The aim of our study was to analyze the frequency of various risk factors and determine predictors of in-hospital mortality among primary intracerebral hemorrhage (PICH) patients, thus providing insight in developing therapeutic strategies to improve the outcome. Methods: A prospective study conducted at a tertiary care hospital. Results: A total of 160 patients (108 male and 52 female) were evaluated. Their ages ranged from 25 to 85 years (mean age was 58.3 ± 11.4 years). Hypertension was the commonest risk factor (74.4%), followed by diabetes mellitus (18.8%) and cigarette smoking (36.3%). The commonest location of ICH was lobar (43.8%) followed by basal ganglia / internal capsule (28.1 %) and multilobar (13.1%). The overall in-hospital mortality was 32.5 %. About one third (32.7%) of the deaths occurred within fi rst 24 hours, this rose to 38.5% within fi rst 2 days and 84.6% within one week. The signifi cant independent predictors of acute in- hospital mortality were Glasgow Coma Scale (GCS) on admission, posterior fossa bleed (OR 11.01; 95% CI 3.21 to 37.81), hematoma volume >60ml (OR 4.72; 95% CI 1.34 to 16.64), mid line shift (OR 3.32; 95% CI 1.05 to 10.50) and intraventricular extension of haemorrhage (OR 5.69; 95% CI 2.24 to 14.47). Conclusion: Low GCS score, posterior fossa bleed, and large hematoma volume were main indicators of mortality following PICH in East coast of Peninsular Malaysia.

Item Type: Article (Journal)
Additional Information: 2309/24622
Uncontrolled Keywords: EMTREE medical terms: adult; aged; article; brain hemorrhage; cigarette smoking; clinical feature; controlled study; decompression surgery; diabetes mellitus; diastolic blood pressure; disease association; disease predisposition; female; Glasgow coma scale; headache; hemiparesis; hemiplegia; human; hypertension; major clinical study; Malaysia; male; mortality; neurologic disease; outcome assessment; prognosis; prospective study; risk assessment; risk factor; rural population; systolic blood pressure; unconsciousness; vomiting
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011)
Kulliyyah of Medicine > Department of Internal Medicine
Kulliyyah of Medicine > Department of Radiology
Depositing User: Prof Dr Mohammed Fauzi Abdul Rani
Date Deposited: 12 Nov 2012 13:49
Last Modified: 10 Mar 2016 10:16
URI: http://irep.iium.edu.my/id/eprint/24622

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