Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient

Sharifudin, Mohd Ariff and Johari, Joehaimey and Omar, Ahmad Sabri and Wan, Zulmi (2011) Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient. Malaysian Orthopaedic Journal, 5 (3). pp. 28-31. ISSN 1985-2533

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Abstract

Langerhans cell histiocytosis of the spine frequently presents as a solitary lesion and rarely results in neurological deficit. Involvement of thyroid tissue is also rare, even in multifocal disease presentations. We present an unusual variant of Langerhans cell histiocytosis in a 37-year-old man presenting with profound quadriparesis and incidental thyroid involvement. MR imaging and skeletal radiographs revealed widespread involvement of the spine. The patient underwent surgical resection of the tumour and stabilization of the spine. Diagnosis was confirmed by histological and immunohistochemistry analysis. Langerhans cell histiocytosis should be included in the differential diagnosis of radiolucent lesions of the spine in adults.

Item Type:	Article (Journal)
Additional Information:	5770/24412
Uncontrolled Keywords:	Adult; Cord Compression With Quadriparesis; Langerhans Cell Histiocytosis; Mass; Spine Tumours; Thyroid
Subjects:	R Medicine > RD Surgery > RD701 Orthopedics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Depositing User:	DR MOHD ARIFF SHARIFUDIN
Date Deposited:	28 Jun 2012 09:08
Last Modified:	15 Jan 2013 22:44
URI:	http://irep.iium.edu.my/id/eprint/24412

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