Sopyan, Iis and Mel, Maizirwan and Fadli, Ahmad and Zulkifli, Nur Izzati
(2010)
Floating porous ceramics for high densiti cell culture in stirred bioreactors.
In: IIUM Research, Innovation & Invention Exhibition (IRIIE 2010), 26 - 27 January 2010, Kuala Lumpur.
Abstract
Floating porous ceramics has been successfully developed using protein foaming-consolidation
method. This method allows the control of porosity not only by the varied concentration of protein but
also by managing the foaming process. Slurries of alumina powders and yolk was prepared by stirring the
mixture and the resulting slip was poured into cylindrical shaped molds. Subsequently, they were
subjected to drying for foaming and/or consolidation. Foaming process condition determined mean pore
size and pore distribution. The dried green bodies of the samples were then burned to remove the pore
creating agent followed by sintering at 1550°C for 2 h. Pore size distribution measurement showed that
macropores of the sintered alumina porous bodies increased with the increased time and temperature of
the drying process and were found in the range 50 - 800 μm. SEM measurement also confirmed this
observation. Less foamed samples show lower shrinkage but higher compressive strength. A shrinkage of
as low as 7.8% was observed for the sample dried at 110ºC but it increased significantly to 29.3% when
dried at 180ºC. The compressive strength of the 110ºC's sample was 5.72 MPa at 43.6% porosity and it
decreased to 4.57 MPa at 50.4% porosity when foamed at 180ºC. Density varied from 0.9 to 1.5 g/cm3
depending on the preparation condition. These results have opened a novel preparative way for porous
ceramics especially alumina-based porous materials designed for biomedical applications such as cell
culture in stirred bioreactor, drug delivery, bone implant etc.
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