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CA19-9 as a non-invasive marker for disease activity in Hepatitis B patients: is there any role?

Nik Ahmad, Nik Nur Fatnoon and Hasmoni, Mohamed Hadzri and Jaafar, Khairul Azhar (2010) CA19-9 as a non-invasive marker for disease activity in Hepatitis B patients: is there any role? In: IIUM Research, Innovation & Invention Exhibition (IRIIE 2010), 26 - 27 January 2010, Kuala Lumpur.

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The combined elevation of tumor markers carbohydrate antigen 19-9 (CA 19-9) and carbohydrate antigen 125 (CA 125) has been shown to be associated with the severity of liver fibrosis in patients with liver disease. We assessed the association between CA 19-9 and viral hepatitis B activity which will allow us to know the usefulness of CA 19-9 as a surrogate marker for the disease activity in hepatitis B patients. Methods: A prospective study involving 60 patients with hepatitis B surface antigen positive carrier was performed. These patients were divided into 2 groups according to HBeAg positivity. Tumor marker CA 19-9 was determined using routine laboratory methods and correlated with the disease activity by measuring hepatitis B viral DNA (HBV DNA) and serum alanine transaminase (ALT) and aspartate transaminase (AST) levels. Results: Eleven (18%) were HBeAg positive and 49 (82%) were HBeAg negative. The mean (standard deviation) age in the former group was 40.7 (11.7) years and in the latter group was 40.8 (12.5) years (p = 0.98). There was no significance difference between the two groups with respect to the levels of serum ALT/AST, HBV DNA and CA 19-9. There was no significant correlation seen between CA 19-9 and serum ALT/AST. It was the same with the levels of HBV DNA. Discussions and conclusion: The use of CA 19-9 as a non-invasive marker for disease activity in patients with hepatitis B infection was not useful. There was no role of CA 19-9 in hepatitis B patients to assess the disease activity.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 3754/23085
Uncontrolled Keywords: IRIIE 2010, CA19-9, Non-Invasive marker, Hepatitis B
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Internal Medicine
Depositing User: Sakinah Kamaludin
Date Deposited: 09 Apr 2012 14:14
Last Modified: 09 Apr 2012 14:15
URI: http://irep.iium.edu.my/id/eprint/23085

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