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Pharmacogenetics of beta adrenergic blockers: their clinical significance

Elsayed, Tarek Mohamed Ali (2009) Pharmacogenetics of beta adrenergic blockers: their clinical significance. INFORMM: Postgraduate Bulletin, 1 (4). pp. 20-23. ISSN 2180-1959

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Beta adrenergic blockers are (ß-blockers) an important class of drugs for the treatment of various cardiovascular diseases, including hypertension, angina pectoris, arrhythmias, hypertrophic cardiomyopathy, and heart failure. They are also indicated for the treatment of migraine headache, anxiety, tremor, and glaucoma. Individual and ethnic variability has been noted in clinical practice and reported in clinical trials. Many factors are anticipated to affect the extent of variability of response to β-blockers including pharmacodynamic variability and pharmacokinetic variability of the parent compounds, as well as, active constituents. In this review, we will present the studies that examine the effect of genetic variability on the pharmacodynamics of β-blockers.

Item Type: Article (Journal)
Additional Information: 6743/22234
Subjects: R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Depositing User: Mr. Tarek Elsayed
Date Deposited: 14 Apr 2013 15:45
Last Modified: 06 Nov 2016 12:31
URI: http://irep.iium.edu.my/id/eprint/22234

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