Fabrication of porous ceramic scaffolds via polymeric sponge method using sol-gel derived strontium doped hydroxyapatite powder

Sopyan, Iis and Mardziah, M. and Ahmad , Zuraida (2011) Fabrication of porous ceramic scaffolds via polymeric sponge method using sol-gel derived strontium doped hydroxyapatite powder. In: 5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, 20-23 June 2011, Kuala Lumpur, Malaysia.

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Abstract

Recently, development of porous calcium phosphates ceramics have raised considerable interest. A porous structure promotes cell attachment, proliferation and provides pathways for biofluids. Therefore, a high porosity with interconnected pore structure generally favors tissue regeneration. In this work, replication of 0, 2, 5, 10 and 15% SrHA (strontium-doped hydroxyapatite) porous scaffolds via polymeric sponge method has been employed using the sol-gel derived SrHA powders. To prepare the porous samples, the synthesized SrHA powders was mixed with distilled water and appropriate amount of dispersing agent followed by drying in the ambient air and specific sintering process. Morphological evaluation by FESEM measurement revealed that the SrHA scaffolds were characterized by macro-micro interconnected porosity, which replicates the morphology of the cancellous bone. Compression test on the porous scaffolds revealed that doping 10 mol% of strontium in HA has increased the compressive strength by a factor of two compared to the undoped HA with 1.81±0.26 MPa at 41% porosity.

Item Type:	Conference or Workshop Item (Full Paper)
Additional Information:	4809/21781
Uncontrolled Keywords:	Porous calcium phosphates, interconnected pore structures, ceramic scaffolds and SrHA porous scaffolds
Subjects:	Q Science > QC Physics T Technology > TA Engineering (General). Civil engineering (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering
Depositing User:	PROF. DR. IIS SOPYAN
Date Deposited:	28 Dec 2012 07:29
Last Modified:	28 Dec 2012 07:30
URI:	http://irep.iium.edu.my/id/eprint/21781

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