Fabrication of porous ceramic scaffolds via polymeric sponge method using sol-gel derived strontium doped hydroxyapatite

Sopyan, Iis and Che Murad, Mardziah and Singh, Ramesh (2012) Fabrication of porous ceramic scaffolds via polymeric sponge method using sol-gel derived strontium doped hydroxyapatite. Applied Mechanics and Materials, 117-19. pp. 829-832. ISSN 1660-9336

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Abstract

Recently, development of porous calcium phosphates ceramics has raised considerable interest. A porous structure promotes cell attachment, proliferation and provides pathways for biofluids. Therefore, a high porosity with interconnected pore structure generally favors tissue regeneration. In this work, replication of 0, 2, 5, 10 and 15% SrHA (strontium-doped hydroxyapatite) porous scaffolds via polymeric sponge method has been employed using the sol-gel derived SrHA powders. To prepare the porous samples, the synthesized SrHA powders were mixed with distilled water and dispersing agent followed by drying in the ambient air and specific sintering process. Morphological evaluation by FESEM measurement revealed that the SrHA scaffolds were characterized by macro-micro interconnected porosity, which replicates the morphology of the cancellous bone. Compression test on the porous scaffolds revealed that doping 10 mol% of strontium in HA has increased the compressive strength by a factor of two compared to the undoped HA with 1.81±0.26 MPa at 41% porosity.

Item Type:	Article (Journal)
Additional Information:	4809/21422
Uncontrolled Keywords:	Porous, hydroxyapatite, polymeric sponge method, ceramic scaffolds, strontium doping, mechanical properties
Subjects:	T Technology > TA Engineering (General). Civil engineering (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering Kulliyyah of Engineering > Department of Manufacturing and Materials Engineering
Depositing User:	PROF. DR. IIS SOPYAN
Date Deposited:	24 Feb 2012 09:17
Last Modified:	28 Dec 2012 07:33
URI:	http://irep.iium.edu.my/id/eprint/21422

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